In addition to copying and updating the synergy.conf file from c:\users\<username>\appdata\local\symless\synergy I also needed to grab some registry keys from an existing system. I exported the following keys from my existing box and imported them on my new machine. [HKEY_LOCAL_MACHINE\SOFTWARE\Synergy] [HKEY_CURRENT_USER\Software\Symless\Synergy] The only side effect is that Synergy is using the old machine name. For me that's fine as I'm decommissioning the old one.