This issue has been haunting me for months. But I just find the strange solution at https://superuser.com/a/1323302/170017 Basically you have to apply some changes to the mouse scrolling speed. Then the scroll wheel (slide if using magic mouse) will work on client machine. I am able to fix it with out rebooting, just make it slow, click [ok], it is already working, make it max again, continue to work.